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Recently, Scientific Reports, an open access journal from the publishers of Nature, published an article titled as "Mechanistic investigation on ROS resistance of phosphorothioated DNA" (doi: 10.1038/srep42823) by Professor Zhao Yilei's Research Group from National Key Lab of Microbial Metabolism at School of Life Science and Biotechnology (SLSB) of Shanghai Jiao Tong University (SJTU). This research combined vivo / in vitro experiments and theoretical calculations and revealed the selectivity and uniqueness of the ROS resistance of phosphorothioated DNA. The achievements are the result of joint efforts of Professor Bai Linquan, Professor Wang Zhijun and Associate Researcher Liang Jingdan from SLSB. Doctoral candidates Wu Tingting and Huang Qiang are respectively the first and second authors of the thesis.

This research was supported by Innovative Research Group Project of National Natural Science Foundation of China and the surface project, the National Key Basic Research and Development Program, the key research project of the National Key Laboratory of Microbial Metabolism, Ministry of Education Key Laboratory of Scientific Engineering Computing and the Open Fund Project of Key Laboratory of Department of Biomedical Education.


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